Cherry tree also commented on the injury of Morata, which was going through a good state of form: “Alvaro He is in a fantastic moment, he is a great player and we also need him for this season finale; hopefully as soon as possible, and well, he will recover to be with us during the next matches, “he said. “Today he started training with the team and hopefully it will be available as soon as possible; He is a great player and we need him right now. We had bad luck with injuries, but Diego already has a good recovery process and hopefully for the next few weeks it may be working “he said during the celebration of the 80th anniversary of the EFE Agency which was held in Madrid. 19 Enrique Cerezo, president of Atlético de MadridAssured EFE who have “had bad luck with injuries”, especially at this time of the season in which they cannot count on the strikers João Felix, Álvaro Morata Y Diego Costa, which returned to training on Wednesday 76 days after surgery for a cervical disc herniation and said he “needs”.
Not everyone who is obese is unhealthy. So say some researchers, who note that a small fraction of overweight people have normal blood sugar levels and blood pressure, and are thus “healthy obese.” Now, scientists have identified a single protein that seems to determine whether obesity is harmful or benign.The protein is a new player in our understanding of how obesity leads to disease, says Alan Saltiel, a cell biologist at the University of Michigan, Ann Arbor, who was not involved in the study.It is well known that obesity leads to a wide range of health problems, from diabetes to heart disease to cancer. So established is the link between extra pounds and illness that last year the American Medical Association voted to classify obesity itself as a disease. Although some researchers have suggested that a small number of obese people are healthy, that idea remains controversial. Instead, the emerging consensus is that healthy obesity is a transient phase, says Ravi Retnakaran, an endocrinologist at the Leadership Sinai Centre for Diabetes in Toronto, Canada. Sooner or later, he says, these outliers will develop metabolic syndrome, a condition in which glucose, cholesterol, and lipid levels soar, causing diabetes and heart disease.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In fact, so-called healthy obese people may already have early signs of disease, which are too muted to show up on routine tests. In a study of more than 14,000 metabolically healthy Korean people last year, scientists found early plaque buildup in the arteries of obese subjects more often than they did in the lean ones.To figure out when the transition from healthy to unhealthy obesity occurs, Harald Esterbauer, an obesity researcher at the Medical University of Vienna, and his colleagues took a closer look at a protein called heme oxygenase-1 (HO-1), which was thought to suppress inflammation—the critical bridge that links obesity to metabolic disease. When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients—as is the case among people who eat a lot—they become inflamed. This leads to the death of some islet cells, in turn decreasing the secretion of insulin and causing type 2 diabetes.To understand the role of HO-1, the researchers examined blood, fat, and liver tissue from a group of 44 obese people and six controls. All the obese subjects were apparently healthy: They had normal fasting glucose levels, no obvious inflammation, and took no medicine. However, there was one critical difference among them: Twenty-seven of the subjects showed early signs of insulin resistance, a precursor of diabetes. Insulin responses were normal in the remaining 17 obese subjects. When Esterbauer’s team biopsied the tissues from both groups, it found HO-1 levels to be nearly twice as high in the insulin-resistant group. The finding suggested that HO-1 was causing the insulin resistance.To be doubly sure, the researchers removed the HO-1 gene from mice. When these knockout mice were fed a high-fat diet, they gained as much weight as normal mice did, but they managed to remain sensitive to insulin. In addition, the knockout mice also showed lower levels of inflammation.The researchers also tried the converse experiment: genetically engineering mice to produce more HO-1. This time, they found that the mice grew insulin-resistant, even when on normal diets.“We believe that HO-1 is a very early marker of metabolic disease,” says Esterbauer, whose team reports its findings today in Cell.Esterbauer’s team also found that levels of the HO-1 protein were slightly higher in healthy obese subjects than in the lean controls. This supports the concept of transient healthy obesity that Retnakaran advocates: Compared with lean, healthy people, obese people are already at a slight disadvantage. Knowing what causes metabolic syndrome may make it easier to treat and diagnose it. Blocking HO-1 in mice controls inflammation, so it could possibly do the same in humans. But before that, it is important to understand how HO-1 causes inflammation, Esterbauer says. “Based on this knowledge, we can then develop drugs that interfere with a specific function of HO-1.”
With the school shooting in Florida and the ensuing March for Our Lives still fresh on their minds, students brought candidates for the 3rd Congressional District together for a town hall Monday night in Vancouver to talk about gun safety and legislation.Solving the problem of gun violence in America isn’t easy, admitted Emma Busch, an 18-year-old student at Vancouver School of Arts and Academics, who helped organize the event hosted by Students Demand Action Clark County.“I really liked what Carolyn (Long) said at the end: We agree about a lot more than we realize,” Busch said. “Don’t go for the dramatic at the start, go for what’s plausible and what people are willing to compromise on and it will make a difference to start now.”Long spoke alongside fellow Democratic candidates Dorothy Gasque and David McDevitt. Republican challenger Earl Bowerman also attended the town hall, providing the opposing view to the Democratic candidates on most questions.Bowerman had to go it alone with a view that was often unpopular as his opponent, incumbent Rep. Jaime Herrera Beutler, R-Battle Ground, did not attend.
Hopefully Kuechly is okay. No matter what PR spin the league puts on it, or regulations that are put in place, it’s unavoidable that football is a violent sport. Last night was an unfiltered reminder of that reality.Luke Kuechly seen sobbing after suffering a knee injury. He was carted off the field. Awful. pic.twitter.com/UCYTmkxPCo— NFL Update (@MySportsUpdate) November 18, 2016 Panthers’ All-Pro linebacker Luke Kuechly was carted off the field after suffering an undisclosed injury while making a tackle in the 4th quarter of the Panthers 23-20 win over the Saints on Thursday night.Kuechly was visibly sobbing, and struggled to catch his breath as he was carted off the field. Players from both teams solemnly gathered around in support as he left the field. Everyone in the NFL is always one hit away.The sight of the indestructible tackling machine crying while being carted off left the crowd at Bank of America Stadium in complete silence.The specific nature of the injury hasn’t been disclosed by the team, but whatever it was left Kuechly shaken up to the point where he couldn’t hold back the tears. Advertisement